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Lambda Light Chains pin

IHC

Lambda Light Chains

Methodology: IHC

Clinical Significance:
Identifies: Kappa and lambda immunoglobulin light chains, expressed by plasma cells and plasmacytoid lymphocytes. Also expressed, but less reliably detected, on B cells with small amounts of cytoplasm. The ratio of kappa-positive to lambda-positive cells in normal/polyclonal B cell and plasma cell populations typically ranges from 1:1 to 2:1. Marked increases in this ratio suggest kappa light chain-restriction, while marked decreases in the ratio (significantly < 1) suggest lambda light chain-restriction. Light chain restriction is conventionally used as a surrogate for clonality among B cell neoplasms. Subcellular Localization: Cytoplasmic

Organ:

Disease State: Amyloid Type Analysis

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm