MALT1 Breakapart pin

FISH

MALT1 Breakapart

Alternate Test Names:
Non Hodgkin Lymphoma (Indolent B-NHL) Panel test
MALT Panel test

Methodology: FISH

Clinical Significance:
The MALT1 beakapart FISH assay is a sensitive test that detects gene rearrangements involving the MALT1 gene but does distinguish between the different MALT1 translocation partners that have been described. The main MALT1 translocations that occur in human MALT lymphomas include the t(11;18)(q21;q21)/API-2-MALT and t(14;18)(q32;q21)/IgH-MALT. Identification of a MALT1 rearrangement is of diagnostic use in atypical B cell proliferations when the diagnosis of MALT lymphoma is being considered.

Probe type: Dual color breakapart

Organ: Blood/Bone Marrow, Body Fluids, Colon & Other GI, Lymph Node / Spleen, Skin & Mucosa

Disease State: B Cell NHL with Plasmacytoid Differentiation, Marginal Zone/MALT Lymphoma

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested