Methodology: FISH

Clinical Significance:
In this reflexive panel a MALT1 breakapart FISH assay is performed. If negative, no more testing is performed. If positive, one additional FISH assay is performed to positively identify and confirm the presence of t(11;18), which is the most common MALT1 gene translocation that occurs in MZBCL.

Organ: Blood/Bone Marrow

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374x2 (reference only; CPTs may vary)

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested