Methodology: FISH

Clinical Significance:
In this reflexive panel a MALT1 breakapart FISH assay is performed. If negative, no more testing is performed. If positive, two additional FISH assays are performed to positively identify and confirm the presence of either the t(11;18) or the t(14;18), which are the two most common MALT1 gene translocations that occur in MZBCL.

Organ: Blood/Bone Marrow

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374x2 (reference only; CPTs may vary)

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested