MALT1 Breakapart (18q21) positive, reflex panel pin

FISH

Panel Components:
t(11;18) MALT1/API2
t(14;18) IGH/MALT1
* Panel makeup subject to change

Methodology: FISH

Clinical Significance:
In this reflexive panel a MALT1 breakapart FISH assay is performed. If negative, no more testing is performed. If positive, two additional FISH assays are performed to positively identify and confirm the presence of either the t(11;18) or the t(14;18), which are the two most common MALT1 gene translocations that occur in MZBCL.

Organ: Blood/Bone Marrow, Body Fluids, Colon & Other GI, Lymph Node / Spleen

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified), Marginal Zone/MALT Lymphoma

CPT Code(s): 88374x2 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested