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IHC
Methodology: IHC
Clinical Significance:
Identifies: Mesothelin, a cell surface protein expressed by mesothelial cells and mesothelioma, but also by ovarian carcinoma and pancreatic adenocarcinoma. Displays significantly less specificity for mesotheliomas than other markers such as WT-1, calretinin, and podoplanin.
Subcellular Localization: Membranous
Organ: Lung
Disease State: Mesothelioma vs. Adenocarcinoma
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm