Methodology: IHC

Clinical Significance:
Identifies: Mesothelin, a cell surface protein expressed by mesothelial cells and mesothelioma, but also by ovarian carcinoma and pancreatic adenocarcinoma. Displays significantly less specificity for mesotheliomas than other markers such as WT-1, calretinin, and podoplanin.

Subcellular Localization: Membranous

Organ: Lung, Pancreas

Disease State: Mesothelioma vs. Adenocarcinoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm