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MLH1 pin

IHC

MLH1

Methodology: IHC

Clinical Significance:
One of the mismatch repair gene products. Loss of expression can help define 'MSI' type colonic and other carcinomas. In general, loss of MLH1 is accompanied by simultaneous loss of PMS2. Subcellular Localization: Nuclear

Organ: OB/GYN

Disease State: Mismatch Repair Genes - Correlates with MSI

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm