MMR (correlates with MSI) pin

IHC

MMR (correlates with MSI)

Panel Components:
Mismatch Repair Genes, including: MLH1; MSH2; MSH6; PMS2

Methodology: IHC

Clinical Significance:
Identifies: Panel of the mismatch repair (MMR) gene products. Loss of expression can help define 'MSI' type colonic and other carcinomas, i.e., tumors deficient in expression of one or more of the MMR gene products.

Organ: Colon & Other GI, OB/GYN, Skin & Mucosa

Disease State:

CPT Code(s): 88342; 88341x3 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm