Alternate Test Names:
Part of MMR Panel (MLH1, MSH2, MSH6, PMS2)
Mismatch Repair Genes

Methodology: IHC

Clinical Significance:
One of the mismatch repair gene products. Loss of expression can help identify tumors in Lynch Syndrome patients, as well as identify 'MSI' type sporadic colonic and other carcinomas. In general, loss of MSH2 is accompanied by simultaneous loss of MSH6.

Subcellular Localization: Nuclear

Organ: Colon & Other GI, OB/GYN, Skin & Mucosa

Disease State: Hereditary Non-Polyposis Colorectal Carcinoma (HNPCC) / Lynch Syndrome, Lynch Syndrome / HNPCC, Microsatellite Instability (MSI), Mismatch Repair Genes - Correlates with MSI

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm