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MSH6 pin

IHC

MSH6

Methodology: IHC

Clinical Significance:
One of the mismatch repair gene products. Loss of expression can help identify tumors in Lynch Syndrome patients, as well as identify 'MSI' type sporadic colonic and other carcinomas. In general, loss of MSH6 is accompanied by simultaneous loss of MSH2, although selective loss of MSH6 alone can also be seen. Subcellular Localization: Nuclear

Organ: OB/GYN

Disease State: Mismatch Repair Genes - Correlates with MSI

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm