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MUM1 pin



Methodology: IHC

Clinical Significance:
Identifies: MUM1 gene product, also known as interferon regulatory factor 4. In hematolymphoid neoplasms, MUM1 is positive in multiple myelomas, lymphoplasmacytic lymphomas, Reed-Sternberg cells of Hodgkin lymphoma and in approximately 50% (up to 75% in some studies) of diffuse large B-cell lymphomas (DLBCL). It is expressed at low levels (i.e., in less than 30% of the cells) in marginal zone lymphomas, follicular lymphomas, and B cell CLL/SLL. It is negative on Burkitt’s lymphoma. Subcellular Localization: Nuclear and cytoplasmic


Disease State: Classical Hodgkin Lymphoma

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm