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MYC Breakapart pin


MYC Breakapart

Methodology: FISH

Clinical Significance:
This sensitive breakapart FISH assay detects any rearrangement involving the MYC gene. Translocations involving the MYC gene on chromosome 8 are characteristic chromosomal aberrations of Burkitt's-type lymphomas/leukemias (BLs). On the molecular level, the MYC gene on 8q24 is juxtaposed to the heavy chain locus on 14q32 in most cases or less commonly to light chain loci on 2q11 and 22q11, resulting in constitutive overexpression of the transcription factor, MYC. The detection of translocations involving MYC is a major aim in the diagnosis of patients with high-grade B cell lymphomas because treatment strategies differ between BL and other high-grade B cell neoplasms. Probe type: Dual color breakapart

Organ: Brain/CNS

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI - OR - • Formalin-fixed, paraffin-embedded tissue (FFPE)