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MYD88 L265P Mutation pin


MYD88 L265P Mutation

Methodology: PCR

Clinical Significance:
The MYD88 L265P mutation is detected in ~90% of lymphoplasmacytic lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM) cases, ~30% of activated/non-germinal center type diffuse large B cell lymphomas, ~40% of central nervous system lymphomas, and ~50% of IgM monoclonal gammopathies of undetermined significance (IgM-MGUS). Of note, the presence of an MYD88 L265P mutation has been associated with a higher risk progression in patients with IgM-MGUS. However, the MYD88 L265P mutation is not exclusively identified in these neoplasms and has been reported in other diagnostic entitites.

Organ: Blood/Bone Marrow

Disease State: Diffuse Large B Cell Lymphoma

CPT Code(s): 81305 (reference only; CPTs may vary)

Turnaround Time: Within 4-8 business days of receipt

Schedule: Thursday

Specimen Requirements:
Formalin-fixed, paraffin-embedded (FFPE) tissue block, 10 FFPE tissue slides, or peripheral blood or bone marrow in EDTA or heparin.