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FISH
Panel Components:
Alternate name: MPD FISH Panel
13q14.3_D13S319
Deletion 20q
CEP8 (trisomy)
Copy Control 9 (CC9) (hyperdiploidy)
* Panel makeup subject to change
Methodology: FISH
Clinical Significance:
Myeloproliferative disorders are a heterogeneous group of conditions that involve the abnormal growth of blood cells in the bone marrow. Included in this group are polycythemia vera, essential thrombocytosis, and primary (or idiopathic) myelofibrosis, also known as myelosclerosis. The prognosis for these diseases largely depends on the type of disorder; several FISH tests can be used prognostically and in conjunction with cytogenetic studies to monitor treatment progress.
Organ: Blood/Bone Marrow
Disease State: Myeloproliferative Neoplasms, Including Chronic Myelogenous Leukemia (CML)
CPT Code(s): 88374, 88367; 88373x2 (reference only; CPTs may vary)
Turnaround Time: Within 3-4 business days of receipt
Schedule: Monday - Friday
Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI