Alternate Test Names:
Naspin A

Methodology: IHC

Clinical Significance:
Identifies: An aspartic protease expressed at high levels by type II pneumocytes of the lung. NapsinA is a highly sensitive and specific marker of pulmonary adenocarcinoma, although it can also be expressed in a subset of renal cell carcinomas and ovarian carcinomas (i.e., clear cell carcinomas).

Subcellular Localization: Granular cytoplasmic

Organ: Lung, OB/GYN

Disease State: Adenocarcinoma, Carcinomas of Unknown Primary, Mesothelioma vs. Adenocarcinoma, Non Small Cell Lung Carcinoma (NSCLC)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm