Methodology: IHC

Clinical Significance:
NKX2.2 is a nuclear transcription factor to the NK2 homeobox 2 gene. This transcription factor is involved in neural morphogenesis as well as the development of neuroendocrine cells, such as those of pancreatic islet cells. The expression of NKX2.2 by IHC is a useful biomarker for distinguishing primitive neuroectodermal tumor/ Ewing sarcoma (PNET/ES) from other small blue round cell tumors, when used as a component of a panel of other tests. Subcellular localization: Nuclear

Organ: Soft Tissue

Disease State: Small, Blue, Round Cell Tumors

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm