Methodology: IHC

Clinical Significance:
NKX2.2 is a nuclear transcription factor to the NK2 homeobox 2 gene. This transcription factor is involved in neural morphogenesis as well as the development of neuroendocrine cells, such as those of pancreatic islet cells. The expression of NKX2.2 by IHC is a useful biomarker for distinguishing primitive neuroectodermal tumor/ Ewing sarcoma (PNET/ES) from other small blue round cell tumors, when used as a component of a panel of other tests. Subcellular localization: Nuclear

Organ: Soft Tissue

Disease State: Small, Blue, Round Cell Tumors

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm