Non Hodgkin Lymphoma (Indolent B-NHL) Panel - Paraffin pin

FISH

Panel Components:
IgH breakapart
t(14;18) IGH/BCL2
BCL6 breakapart
t(11;14) CCND1/IGH
MALT1 breakapart
* Panel makeup subject to change

Methodology: FISH

Clinical Significance:
These FISH studies identify the genetic alteration characteristic of several major categories of non Hodgkin B cell lymphoma. These include the t(14;18) IGH/BCL2 and BCL6 family of rearrangements identified in follicular lymphomas, the t(11;14) identified in mantle cell lymphoma, and MALT1 gene rearrangements that are identified in a subset of marginal zone B cell lymphomas. The identification of an IGH rearrangement in isolation can also aid in the diagnosis of atypical lymphoid proliferations even when its translocation partner is not elucidated.

Organ:

Disease State:

CPT Code(s): 88374x5 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested

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