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These FISH studies identify the genetic alteration characteristic of several major categories of non Hodgkin B cell lymphoma. These include the t(14;18) IGH/BCL2 and BCL6 family of rearrangements identified in follicular lymphomas, the t(11;14) identified in mantle cell lymphoma. The identification of an IGH rearrangement in isolation can also aid in the diagnosis of atypical lymphoid proliferations even when its translocation partner is not elucidated.
Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)
CPT Code(s): 88374x4 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI