Non Hodgkin Lymphoma (Indolent B-NHL) Panel - Wet pin

FISH

Panel Components:
IgH breakapart
t(14;18) IGH/BCL2
BCL6 breakapart
t(11;14) CCND1/IGH
* Panel makeup subject to change

Methodology: FISH

Clinical Significance:
These FISH studies identify the genetic alteration characteristic of several major categories of non Hodgkin B cell lymphoma. These include the t(14;18) IGH/BCL2 and BCL6 family of rearrangements identified in follicular lymphomas, the t(11;14) identified in mantle cell lymphoma, and MALT1 gene rearrangements that are identified in a subset of marginal zone B cell lymphomas. The identification of an IGH rearrangement in isolation can also aid in the diagnosis of atypical lymphoid proliferations even when its translocation partner is not elucidated.

Organ: Blood/Bone Marrow, Body Fluids, Colon & Other GI, Lung, Lymph Node / Spleen, Skin & Mucosa, Thymus (Mediastinal Mass)

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified), Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Mantle Cell Lymphoma, Marginal Zone/MALT Lymphoma

CPT Code(s): 88374x4 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI