Methodology: IHC

Clinical Significance:
Identifies: A nuclear protein (NUT) expressed normally in germ cells of the testis and ovary. NUT midline carcinoma (NMC) is defined by the presence of chromosomal rearrangement involving the NUT gene on chromosome 15q14 and immunohistochemically detectable expression of the NUT protein.

Subcellular Localization: Nuclear (speckled)

Organ:

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm