Alternate Test Names:
PAX5

Methodology: IHC

Clinical Significance:
Identifies: A nuclear protein expressed throughout B cell maturation prior to the plasma cell stage, at which point it is no longer expressed. PAX-5 is strongly expressed in the great majority of mature and immature B cell neoplasms, and in nodular lymphocyte predominance Hodgkin lymphoma. PAX-5 is expressed at decreased intensity in classical Hodgkin's lymphoma, and is not expressed in the great majority of plasma cell neoplasms.

Subcellular Localization: Nuclear

Organ:

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified), Classical Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, Precursor B-Lymphoblastic Lymphoma/Leukemia (B-ALL)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm