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Identifies: Programmed cell death protein 1 (PD-1; CD279), a cell surface protein in the immunoglobulin superfamily that is a marker of follicular helper T (TFH) cells, and can be expressed by other subsets of T cells. TFH cells are normally found in the germinal centers of benign lymphoid tissues, and are the putative cell of origin for some T cell non-Hodgkin lymphomas, including angioimmunoblastic T cell lymphomas. The interaction of PD-1 with either of its two ligands - PD-L1 and PD-L2 - typically diminishes T cell immune responses by stimulating their programmed cell death, such that PD-L1 and PD-L2 expression by tumor cells is thought to be a major mechanism by which cancer evades the immune system. Accordingly, anti-PD-1 therapy represents a promising new therapy designed to enhance ability of the immune system to target and kill cancer cells. Subcellular Localization: Membranous or cytoplasmic
Disease State: Angioimmunoblastic T Cell Lymphoma
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm