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PD-1 (CD279) pin

IHC

PD-1 (CD279)

Methodology: IHC

Clinical Significance:
Identifies: Programmed cell death protein 1 (PD-1; CD279), a cell surface protein in the immunoglobulin superfamily that is a marker of follicular helper T (TFH) cells, and can be expressed by other subsets of T cells.  TFH cells are normally found in the germinal centers of benign lymphoid tissues, and are the putative cell of origin for some T cell non-Hodgkin lymphomas, including angioimmunoblastic T cell lymphomas.  The interaction of PD-1 with either of its two ligands - PD-L1 and PD-L2 - typically diminishes T cell immune responses by stimulating their programmed cell death, such that PD-L1 and PD-L2 expression by tumor cells is thought to be a major mechanism by which cancer evades the immune system.  Accordingly, anti-PD-1 therapy represents a promising new therapy designed to enhance ability of the immune system to target and kill cancer cells. Subcellular Localization: Membranous or cytoplasmic

Organ:

Disease State: Angioimmunoblastic T Cell Lymphoma

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm