PD-1 (CD279) pin

IHC

PD-1 (CD279)

Alternate Test Names:
PD1; Programmed cell death protein 1; CD279

Methodology: IHC

Clinical Significance:
Identifies: Programmed cell death protein 1 (PD-1; CD279), a cell surface protein in the immunoglobulin superfamily that is a marker of follicular helper T (TFH) cells, and can be expressed by other subsets of T cells. TFH cells are normally found in the germinal centers of benign lymphoid tissues, and are the putative cell of origin for some T cell non-Hodgkin lymphomas, including angioimmunoblastic T cell lymphomas. The interaction of PD-1 with either of its two ligands - PD-L1 and PD-L2 - typically diminishes T cell immune responses by stimulating their programmed cell death, such that PD-L1 and PD-L2 expression by tumor cells is thought to be a major mechanism by which cancer evades the immune system. Accordingly, anti-PD-1 therapy represents a promising new therapy designed to enhance ability of the immune system to target and kill cancer cells.

Subcellular Localization: Membranous or cytoplasmic

Organ:

Disease State: Angioimmunoblastic T Cell Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only