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Rearrangement of PDGFRB is one of several molecularly defined mechanisms identified in eosinophilia-associated myeloid and lymphoid neoplasms. These neoplasms often present with features similar to chronic myelomonocytic leukemia (CMML), including leukocytosis with anemia and thrombocytopenia, and hypercellular bone marrow with increased reticulin fibrosis. The most common translocation partner is ETV6 [t(5;12)(q33;p13), although more than 20 others have been described. The translocation encodes a constitutively activated tyrosine kinase that responds to imatinib therapy.
Organ: Blood/Bone Marrow
CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI