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Alternate Test Names:
Rearrangement of PDGFRB is one of several molecularly defined mechanisms identified in eosinophilia-associated myeloid and lymphoid neoplasms. These neoplasms often present with features similar to chronic myelomonocytic leukemia (CMML), including leukocytosis with anemia and thrombocytopenia, and hypercellular bone marrow with increased reticulin fibrosis. The most common translocation partner is ETV6 [t(5;12)(q33;p13), although more than 20 others have been described. The translocation encodes a constitutively activated tyrosine kinase that responds to imatinib therapy.
Organ: Blood/Bone Marrow
CPT Code(s): 88374
Turnaround Time: Within 3-4 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI