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One of the mismatch repair gene products. Loss of expression can help identify tumors in Lynch Syndrome patients, as well as identify 'MSI' type sporadic colonic and other carcinomas. In general, loss of PMS2 is accompanied by simultaneous loss of MLH1. Cellular Localization: Nuclear
Disease State: Mismatch Repair Genes - Correlates with MSI
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm