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RET Breakapart pin


RET Breakapart

Methodology: FISH

Clinical Significance:
The purpose and clinical utility of this FISH assay is to evaluate a patient tumor sample for the presence of a RET gene rearrangement. Tumors that contain a RET gene rearrangement may be responsive to treatment with tyrosine kinase inhibitor drug therapy such as vandetanib or cabozantenib. Therefore, patients that are positive for the rearrangement may benefit from this treatment. Tumor types that contain RET gene translocations that have been described include those resulting from non-small cell lung cancer as well as thyroid cancer.

Organ: Lung

Disease State: Mesothelioma vs. Adenocarcinoma

CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested