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ROS-1 is a an orphan receptor tyrosine kinase that is phylogenetically related to the ALK tyrosine kinase gene. ROS-1 rearrangements have been found to occur in approximately 2% of lung adenocarcinomas and several gene fusion partners have been identified including CD74, LRIG3, SDC4, TPM3, and FIG. Tumors that harbor a ROS-1 gene rearrangement have been found to be responsive to treatment with the ALK inhibitor drug crizotinib (Xalkori). Recent studies have demonstrated that FISH can be used to identify ROS-1 rearrangements in lung adenocarcinoma. A positive result with this test would therefore indicate that the patient may respond to treatment with crizotinib*. *NOTE: Determining insurance eligibility is the responsibility of the patient and their physician.
Disease State: Mesothelioma vs. Adenocarcinoma
CPT Code(s): 88374 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested