ROS1 pin

IHC

Alternate Test Names:
ROS, MCF3, c-ros-1

Methodology: IHC

Clinical Significance:
ROS1 (also know as ROS, MCF3 and c-ros-1) is a proto-oncogene highly expressed in a variety of tumor cells. Immunohistocheminal localization of ROS1 can be used to distinguish cancers containing the ROS1 translocation and may serve as a possible surrogate for ROS1 FISH using a breakapart probe.

The c-ROS oncogene 1 receptor tyrosine kinase (ROS1) gene is located on human chromosome 6. Rearrangement of ROS1 results in the production of constitutively active fusion proteins that have been reported in non-small cell lung cancers (NSCLC). ROS1 fusion protein plays a central role in cancer growth and development by increasing the translation of genes associated with cell proliferation, migration and metastasis. Published data suggest that ROS1-rearranged cancers respond to ALK inhibitors. The performance characteristics of this antibody, as established by PhenoPath, justify its use as an alternative to, or in conjunction with, ROS1 FISH for the identification of lung adenocarcinomas harboring ROS1 gene translocations.

Subcellular Localization: Cytoplasmic

Organ: Lung

Disease State: Non Small Cell Lung Carcinoma (NSCLC)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm