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IHC
Methodology: IHC
Clinical Significance:
Nuclear localization of SF-1 can be used to distinguish sex cord-stromal tumors (SCST) from non-sex cord-stromal tumors (e.g., borderline tumors, serous carcinomas, etc.) and is therefore useful in the differential diagnosis of these neoplasms. Antibodies to SF-1 should be run in a panel with other sex cord-stromal tumor markers, such as inhibin and calretinin.
Subcellular localization: Nuclear
Organ: OB/GYN
Disease State:
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm