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SMMHC (smooth muscle myosin heavy chain) pin


SMMHC (smooth muscle myosin heavy chain)

Methodology: IHC

Clinical Significance:
Identifies: A component of smooth muscle myosin, a protein expressed in cells and tumors showing smooth muscle or myoepithelial differentiation. May also be expressed in myofibroblasts. Most commonly employed to distinguish invasive v. in situ breast carcinoma, usually in conjunction with at least one other myoepithelial marker, e.g., p63. Subcellular Localization: Cytoplasmic

Organ: Breast

Disease State: Breast Cancer

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm