Alternate Test Names:
SRY-related HMG-Box gene 10

Methodology: IHC

Clinical Significance:
SOX10 is a highly specific and sensitive nuclear transcription factor found in nerve sheath tumors (e.g., schwannomas) and melanomas. It is also expressed in the majority of desmoplastic and spindle cell melanomas. While S100 is also positive on these tumors, SOX10 is far more specific than S100. SOX10 has also been found to be expressed in salivary gland as well as soft tissue tumors showing myoepithelial differentiation.

SOX 10 should be employed in the context of a panel of antibodies for the identification of melanoma and nerve sheath tumors.

Subcellular Localization: Nuclear

Organ: Skin & Mucosa, Soft Tissue

Disease State: Melanoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm