SOX11 pin

IHC

SOX11

Alternate Test Names:
MRQ-58, Sox-11, SOX-11

Methodology: IHC

Clinical Significance:
SOX11 is a transcription factor expressed in almost all cases of mantle cell lymphoma (MCL), including the rare entity cyclin D1-negative MCL. It is not expressed in potential MCL mimics such as atypical chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL), follicular lymphoma, and marginal zone lymphoma (Soldini D, et al. Am J Surg Path 38:86-93, 2014).

Subcellular Localization: Nuclear

Organ: Blood/Bone Marrow, Lymph Node / Spleen

Disease State: Mantle Cell Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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