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Alternate Test Names:
This sensitive breakapart assay detects any translocation involving the SYT gene. The most common of these translocations is the t(X;18) that juxtaposes the SYT gene with the SS18 gene and is the hallmark translocation of synovial sarcoma. Rearrangement of the SYT gene in these tumors can be detected in over 90% of cases. Evaluation for an SYT rearrangement is thus a useful test when synovial sarcoma is a diagnostic consideration.
Probe type: Dual color breakapart
Organ: Soft Tissue
Disease State: Spindle Cell Tumors / Sarcoma Subtyping
CPT Code(s): 88374 (reference only; CPTs may vary)
Turnaround Time: Within 3-4 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested