STAT 6 pin

IHC

STAT 6

Alternate Test Names:
STAT6
Signal Transducer and Activator of Transcription

Methodology: IHC

Clinical Significance:
STAT (Signal Transducer and Activator of Transcription) proteins are transcription factors that are normally located in the cytoplasm in latent form and migrate to the nucleus on cytokine exposure and subsequent phosphorylation. Studies have demonstrated the presence of recurrent fusions between NAB2 and STAT6 in chromosome 12q13 in the majority of solitary fibrous tumors/hemangiopericyomas. Nuclear STAT6 immunoreactivity has been reported as a surrogate marker for the NAB2-STAT6 gene fusion, which is the defining driver mutation of solitary fibrous tumor/hemangiopericytoma.

Subcellular Localization: nuclear

Organ: Soft Tissue

Disease State: Hemangiopericytoma, Solitary Fibrous Tumor, Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only