Synaptophysin pin

IHC

Synaptophysin

Methodology: IHC

Clinical Significance:
A highly sensitive and specific marker of neural and neuroendocrine cells and tumors. Shows superior sensitivity to chromogranin A in the context of high grade neuroendocrine carcinomas. Also expressed in PNET/ES and other tumors showing neural differentiation.

Subcellular Localization: Cytoplasmic, finely granular

Organ: Colon & Other GI, Lung, Pancreas, Thyroid

Disease State: Carcinomas of Unknown Primary, Mesothelioma vs. Adenocarcinoma, Non Small Cell Lung Carcinoma (NSCLC), Small, Blue, Round Cell Tumors

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only