Methodology: FISH

Clinical Significance:
The t(11;18)(q21;q21), which juxtaposes the MALT1 gene located on chromosome 11q21 with the API2 (also known as BIRC3) gene on 18q21, is detected in approximately 10-20% of patients with extranodal low grade marginal zone B-cell lymphomas of MALT type (i.e., MALT lymphomas) and is particularly prevalent in those of gastric (20-30%) and lung (~50%) origin. It is of particular clinical import as patients with t(11;18)(q21;q21)-positive gastric MALT lymphomas do not respond to Helicobacter pylori eradication therapy, are associated with more advanced-stage disease, and usually do not show transformation to large cell lymphoma. Probe type: Dual color, dual fusion translocation

Organ: Blood/Bone Marrow

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested