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t(11;18) MALT1/API2 (& MALT1/BIRC3) pin

FISH

t(11;18) MALT1/API2 (& MALT1/BIRC3)

Methodology: FISH

Clinical Significance:
The t(11;18)(q21;q21), which juxtaposes the MALT1 gene located on chromosome 11q21 with the API2 (also known as BIRC3) gene on 18q21, is detected in approximately 10-20% of patients with extranodal low grade marginal zone B-cell lymphomas of MALT type (i.e., MALT lymphomas) and is particularly prevalent in those of gastric (20-30%) and lung (~50%) origin. It is of particular clinical import as patients with t(11;18)(q21;q21)-positive gastric MALT lymphomas do not respond to Helicobacter pylori eradication therapy, are associated with more advanced-stage disease, and usually do not show transformation to large cell lymphoma. Probe type: Dual color, dual fusion translocation

Organ: Blood/Bone Marrow

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested