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t(14;16) IGH/MAF pin


t(14;16) IGH/MAF

Methodology: FISH

Clinical Significance:
This FISH assay detects the t(14;16)(q32;q23) which juxtaposes the CMAF gene with the IGH gene. This translocation has been identified as a recurrent and prognostic translocation in plasma cell myeloma and has been associated with a poor prognosis with shorter overall survival. Plasma cell myeloma is a bone marrow-based plasma cell proliferation characterized by elevated circulating monoclonal paraprotein production and multifocal osteolytic bone lesions. Separation of plasma cell myeloma into different subgroups based upon recurrent chromosomal alterations may provide important prognostic information and may provide the basis for particular therapy for some plasma cell myeloma subgroups. Probe type: Dual color dual fusion translocation

Organ: Brain/CNS

Disease State: Plasma Cell Myeloma/Neoplasm

CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI - OR - • Formalin-fixed, paraffin-embedded tissue (FFPE)