Alternate Test Names:
t(14;18)(q32;q21) MALT1
MALT1 (18q21) positive Reflex Panel test

Methodology: FISH

Clinical Significance:
This dual color dual fusion FISH assay secifically detects the t(14;18)(q32;q21). This translocation, which juxtaposes the MALT1 gene on chromosome 18q21 with the IGH chain gene on 14q32, is detected in approximately 10% of patients with MALT lymphomas, namely in MALT lymphomas of the liver, skin, ocular adnexa, and salivary gland, but typically does not occur in MALT lymphomas of the stomach, intestine, lung, thyroid, or breast.

Probe type: Dual color, dual fusion translocation

Organ: Blood/Bone Marrow, Body Fluids, Colon & Other GI, Lymph Node / Spleen

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified), Marginal Zone/MALT Lymphoma

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested