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Alternate Test Names:
Acute Promyelocytic Leukemia Panel test
Acute Myelogenous Leukemia Panel test
This FISH assay detects the t(15;17)(q22;q12) involving the PML and RARA genes. It is the most common translocation for acute promyelocytic leukemia (AML-M3) which is a distinct form of acute myeloid leukemia that accounts for approximately 10% of cases and is characterized by promyelocytes, thrombocytopenia, disseminated intravascular coagulation (DIC), and sensitivity to all-trans-retinoic acid (ATRA).
Probe type: Dual color dual fusion translocation
CPT Code(s): 88374 (reference only; CPTs may vary)
Turnaround Time: Within 3-4 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI - OR -
• Formalin-fixed, paraffin-embedded tissue (FFPE)