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t(8;21) (RUNX1/RUNX1T1) pin


t(8;21) (RUNX1/RUNX1T1)

Alternate Test Names:
Acute Myelogenous Leukemia Panel test

Methodology: FISH

Clinical Significance:
FISH studies for t(8;21) are clinically indicated in new diagnoses of acute myeloid leukemia (AML) for proper diagnostic classification, as the t(8;21) is a recurrent chromosomal abnormality in AML. FISH testing for this abnormality may also be indicated for follow-up studies to monitor disease progression and response to therapy.

t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), especially in FAB M2. Clinically, this type of AML is found in 5-12% of AML, often shows eosinophilia, and has a high complete remission rate with conventional chemotherapy.

Probe type: Dual fusion, dual color

Organ: Blood/Bone Marrow, Body Fluids, Lymph Node / Spleen

Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma, Myelodysplastic Syndromes

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI

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