Alternate Test Names:
Acute Myelogenous Leukemia Panel test
FISH studies for t(8;21) are clinically indicated in new diagnoses of acute myeloid leukemia (AML) for proper diagnostic classification, as the t(8;21) is a recurrent chromosomal abnormality in AML. FISH testing for this abnormality may also be indicated for follow-up studies to monitor disease progression and response to therapy.
t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), especially in FAB M2. Clinically, this type of AML is found in 5-12% of AML, often shows eosinophilia, and has a high complete remission rate with conventional chemotherapy.
Probe type: Dual fusion, dual color
CPT Code(s): 88374 (reference only; CPTs may vary)
Turnaround Time: Within 3-4 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI