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t(9;22) BCR/ABL pin


t(9;22) BCR/ABL

Alternate Test Names:
t(9;22)(q34;q11.2) (BCR/ABL)
Acute Lymphocytic Leukemia Panel test
CML Panel test

Methodology: FISH

Clinical Significance:
This FISH assay detects the t(9;22), which results in the BCR-ABL fusion gene. The hallmark of chronic myelogenous leukemia (CML) is the presence of the BCR-ABL fusion gene associated with the Philadelphia chromosome (Ph). All cases of CML have a t(9;22) or variant and detection of this genetic abnormality is important in the diagnosis of CML. The BCR/ABL fusion gene resulting from the t(9;22) is the target for the tyrosine kinase inhibitor drug imatinib.

Probe type: Dual color dual fusion translocation

Organ: Blood/Bone Marrow, Body Fluids

Disease State: Myeloproliferative Neoplasms, Including Chronic Myelogenous Leukemia (CML), Precursor B-Lymphoblastic Lymphoma/Leukemia (B-ALL)

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI - OR -
• Formalin-fixed, paraffin-embedded tissue (FFPE)

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