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TCL1 pin



Methodology: IHC

Clinical Significance:
Identifies a protein present in both the cytoplasm and nucleus of the following:  immature normal T-cells; T-cell prolymphocytic leukemia (in which TCL-1 overexpression due to chromosomal translocation is the key pathogenetic event); a variety of B-cell lymphoproliferative disorders including CLL/SLL; and blastic plasmacytoid dendritic cell neoplasms.  TCL-1 protein function has been studied predominately in T-cells, in which it has been demonstrated to bind to the AKT protooncogene and to enhance both AKT enzymatic activity and translocation from cytoplasm to nucleus. Subcellular Localization: Nuclear, some cytoplasmic


Disease State: Blastic Plasmacytoid Dendritic Cell Neoplasm

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm