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TCR-beta gene rearrangement pin


TCR-beta gene rearrangement

Methodology: PCR

Clinical Significance:
This PCR-based assay evaluates T cell clonality as part of the diagnostic work-up of specimens containing atypical T cell populations. It can be used in conjunction with TCR-gamma PCR studies in order to increase the likelihood of identifying such populations in reactive as well as neoplastic T cell proliferations. TCR-β clonal rearrangements can be identified in both mature and immature T cell lymphomas and leukemias and can aid in the diagnosis of such neoplasms in conjunction with other diagnostic modalities such as histology, immunohistochemistry and flow cytometry.

Organ: Skin & Mucosa

Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous)

CPT Code(s): 81340; 88381 may apply; G0452 may apply. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 3-5 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 5 ml in EDTA (purple top) / Acceptable: 5 ml in sodium heparin (green top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in EDTA (purple top) / Acceptable: 1-2 ml in sodium heparin (green top) - OR - • Fresh tissue in RPMI - OR - • Formalin-fixed, paraffin-embedded tissue (FFPE)