Alternate Test Names:
Terminal deoxynucleotidyltransferase

Methodology: IHC

Clinical Significance:
Identifies: Terminal deoxynucleotidyltransferase, a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and also the majority of precursor B- and T-lymphoblastic leukemias/lymphomas. TdT is aberrantly expressed in a small subset of acute myeloid leukemias.

Subcellular Localization: Nuclear

Organ:

Disease State: Blastic Plasmacytoid Dendritic Cell Neoplasm, Small, Blue, Round Cell Tumors

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm