Methodology: FISH

Clinical Significance:
Translocations involving the TFE3 gene at Xp11.2 have been described in a subset of tumors including renal cell carcinomas as well as in alveolar soft part sarcoma (see reference 3). TFE3 FISH is therefore indicated where the presence of a TFE3 translocation is being considered during the pathologic evaluation of the tumor.

Organ: Kidney

Disease State:

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested