Thymidylate Synthase (TS) pin

IHC

Thymidylate Synthase (TS)

Alternate Test Names:
TS

Methodology: IHC

Clinical Significance:
Identifies: The enzyme used to generate thymidine monophosphate (dTMP), which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair. TS is an important target for certain chemotherapeutic drugs. It is employed as a prognostic and predictive marker in colonic adenocarcinoma.

Subcellular Localization: Nuclear and cytoplasmic

Organ: Colon & Other GI

Disease State:

CPT Code(s): 88360 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only