Methodology: IHC

Clinical Significance:
Identifies: A dimeric protein produced by and used within the thyroid gland. While it is an excellent marker of metastatic thyroid carcinoma, technical issues with anti-thyroglobulin antibodies, often producing nonspecific signal, make the combination of TTF-1 and PAX-8 expression a better marker of these tumors.

Subcellular Localization: Cytoplasmic

Organ: Thyroid

Disease State:

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm