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UroVysion FISH pin

FISH

Alternate Test Names:
UroVysion, urine FISH

Methodology: FISH

Clinical Significance:
Bladder cancer is the fourth most common cancer in the United States. Ninety percent of bladder cancers are classified as Transitional Cell Carcinoma (TCC), which are further categorized into 4 clinically relevant subgroups at pathologic staging. While clinical outcome differs for each subgroup, 3 of the 4 groups are “superficial” at presentation but have a high probability (50-80%) of recurrence, and may progress to invasive tumors.

Patients with these superficial bladder cancers are regularly monitored for recurrence and progression, typically with cystoscopy and urine cytology. Both of these methods have shown low sensitivity for detecting bladder cancer; newer studies, however, have shown that FISH analysis for aneuploidy of specific chromosomes may be a useful adjunct in detecting bladder cancer

Organ:

Disease State:

CPT Code(s): 88121

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
20 mL urine in 10 mL PhenoPath-provided Carbowax fixative (in 50 mL tube)
OR at least 20 mL urine

Ship immediately on ice. If shipment is delayed, store in refrigerator and ship within 24 hours