Villin pin

IHC

Villin

Methodology: IHC

Clinical Significance:
Identifies: An actin binding protein that is a marker of carcinomas of GI tract origin. Villin, along with CDX2, is a highly specific and fairly sensitive marker of colorectal as well as “noncolorectal GI tract” (e.g., pancreatobiliary tract) derived carcinomas. In the latter tumors, a brush border pattern is characteristic. A subset of lung adenocarcinomas are also villin positive.

Subcellular Localization: Cytoplasmic, membranous, “brush border” pattern

Organ: Colon & Other GI, Liver, Pancreas

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only