Methodology: IHC

Clinical Significance:
Identifies: The intermediate filament protein associated with cells manifesting mesenchymal differentiation; also co-expressed with cytokeratin in a subset of carcinomas. While a subset of carcinomas co-express vimentin along with cytokeratin, the use of organ restricted markers such as TTF-1, PAX-8, etc., is preferred to vimentin in this setting. There are very few remaining applications for use of this antibody in current diagnostic pathology.

Subcellular Localization: Cytoplasmic

Organ:

Disease State: Large Cell Undifferentiated Malignant Neoplams

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm