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IHC
Methodology: IHC
Clinical Significance:
Identifies: The intermediate filament protein associated with cells manifesting mesenchymal differentiation; also co-expressed with cytokeratin in a subset of carcinomas. While a subset of carcinomas co-express vimentin along with cytokeratin, the use of organ restricted markers such as TTF-1, PAX-8, etc., is preferred to vimentin in this setting. There are very few remaining applications for use of this antibody in current diagnostic pathology.
Subcellular Localization: Cytoplasmic
Organ:
Disease State: Large Cell Undifferentiated Malignant Neoplams
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm