Methodology: IHC

Clinical Significance:
Identifies: ZAP-70, a cytoplasmic protein ubiquitously expressed in T cells and NK cells, and in neoplasms derived from these cells. Most normal B cells do not express ZAP-70, but it is expressed in a variety of B cell non-Hodgkin lymphomas. Importantly, expression of ZAP-70 in chronic lymphocytic leukemia/small lymphocytic lymphoma strongly correlates with a lack in immunoglobulin gene mutation, and has been associated with an adverse prognosis. Subcellular Localization: Cytoplasmic and nuclear

Organ:

Disease State: Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm