Methodology: IHC

Clinical Significance:
Identifies: ZAP-70, a cytoplasmic protein ubiquitously expressed in T cells and NK cells, and in neoplasms derived from these cells. Most normal B cells do not express ZAP-70, but it is expressed in a variety of B cell non-Hodgkin lymphomas. Importantly, expression of ZAP-70 in chronic lymphocytic leukemia/small lymphocytic lymphoma strongly correlates with a lack in immunoglobulin gene mutation, and has been associated with an adverse prognosis. Subcellular Localization: Cytoplasmic and nuclear

Organ:

Disease State: Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL)

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm